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¹Beyoğlu Göz Eğitim ve Araştırma Hastanesi, İstanbul, Uzm. Dr.
²Beyoğlu Göz Eğitim ve Araştırma Hastanesi, İstanbul, Doç. Dr.
³Beyoğlu Göz Eğitim ve Araştırma Hastanesi, İstanbul, Prof. Dr. Purpose: To evaluate the effect of trabeculectomy on corneal endothelial cells and related factors.
Materials and Methods: 39 eyes of 36 patients who had undergone trabeculectomy were evaluated prospectively. Age, intraocular surgery history, pseudoexfoliation, diabetes mellitus, glaucoma type, intraoperative mitomycin-C (MMC) and postoperative 5-Flourouracil (5-FU) use and postoperative complications were recorded. Preoperative, postoperative 1st, 3rd and 6th month best corrected visual acuity, intraocular pressure (IOP), endothelial cell area and count per mm² measured by specular microscope were compared.
Results: Endothelial cell count was 2167.2±551.1 preoperatively, 2119.5±618.2 in the postoperative 1st month, 1908.8±661.8 in the postoperative 3rd month and 2163.7±658.4 in the postoperative 6th month. There were no statistical significant differences between pre and postoperative endothelial cell areas or counts (p>0.05). A statistically significant IOP drop was obtained in all postoperative controls compared to preoperative IOP (p<0.05). We observed that eyes which had a history of intraocular surgery and narrow angle glaucoma had lower endothelial cell counts preoperatively. We observed that intraoperative MMC and postoperative 5-FU had no effect on endothelial cells but postoperative anterior chamber narrowing decreased the endothelial cell count.
Conclusion: We suggest that eyes with or intraocular surgery history, narrow angle glaucoma and postoperative anterior chamber narrowing should be evaluated more carefully with endothelial cell count before and after trabeculectomy. Keywords : Trabeculectomy, corneal endothelial cells