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¹Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Van, Doç. Dr
²Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Van, Asist. Dr
³Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Van, Prof. Dr Purpose: To evaluate the intraocular pressure (IOP) lowering effect of latanoprost therapy in long-term follow up and to observe the development of any resistance to therapy like that to other antiglaucoma medications.
Materials and Methods: Thirty-six eyes of 24 patients with primary open angle glaucoma (POAG) seen in the Ophthalmological Department of Yüzüncü Yil University Medicine Faculty Hospital in 1999-2004 were evaluated. The mean follow up period was 61.27±6.51 months (range 48-65). The patients had no history of intraocular surgery or inflammatory diseases like uveitis or herpetic keratitis. Patients were treated with latanoprost 0.005% monotherapy. Ten of the patients were female and 14 were male. The mean age was 66.33±11.60 years (range 45-87). They were screened in the Glaucoma Department.
Results: Before therapy the mean IOP was 22.8±3.15 mmHg. The mean IOP after therapy in year 1 was 16.45±3.29 mmHg (25.81% drop), year 2 was 15.0±1.84 mmHg (32.37% drop), in year 3 was 16.40±2.4 mmHg (26.06% drop), in year 4 was 16.00±1.41 mmHg (27.86% drop), and in year 5 was 16.75±2.50 mmHg (24.48% drop). Decreases in IOP measurements compared to the pretreatment values of the all follow up measurements were statistically significant, while there was no statistically significant difference between 1^st and 5^th years’ follow-up results.
Conclusion: Latanoprost monotherapy in POAG is effective in long-term (5 years) follow-up. Keywords : POAG, latanoprost, beta blocker, antiglaucoma medications