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¹S.B. Ulucanlar Göz Eğitim ve Araştırma Hastanesi, Göz, Ankara, Uzm. Dr.
²S.B. Ulucanlar Göz Eğitim ve Araştırma Hastanesi, Göz, Ankara, Doç. Dr.
³S.B. Ulucanlar Göz Eğitim ve Araştırma Hastanesi, Göz, Ankara, Asist. Dr.
⁴S.B. Ulucanlar Göz Eğitim ve Araştırma Hastanesi, Göz, Ankara, Prof. Dr. Purpose: To investigate potential safety and efficacy of nonpreserved amniotic membrane transplantation (NP-AMT) in ocular surface reconstruction.
Materials and Methods: NP-AMT was performed on 18 eyes (17 patients) having persistent epithelial defect due to chemical injury, postinfectious keratitis, band keratopathy (BK), and topical anesthetic abuse. All patients underwent detailed ophthalmic examination including lid and ocular motility, extraocular examination, Schirmer tear test, visual acuity, tonometry, slit-lamp and fundus examination which were carried out before and after the treatment. Main outcome measures were complete surface epithelialization and epithelialization time.
Results: NP-AMT was considered successful in 16 cases (88.9%) with complete surface epithelialization. Two eyes (11.1%) had persistent corneal epithelial defect and stromal lysis despite NP-AMT and considered as surgical failure. Of these patients, one had nonherpetic postinfectious keratitis and one had topical anesthetic abuse. The overall visual improvement was detected in 11 (61.1%) of 18 eyes. The visual improvement was observed in 4 (50%) patients with postinfectious keratitis, 3 (60%) patients with chemical injury, and 3 (100%) patients with BK. Seven eyes (38.9%) maintained same visual acuity, and none of the eyes had a decrease in visual acuity. There were no infectious, inflammatory, immunologic, or toxic/allergic reactions related to NP-AMT.
Conclusion: NP-AMT is a useful treatment modality in patients with persistent epithelial defects due to infectious keratitis and chemical injury. Moreover, it is a safe and effective method to restore a stable corneal epithelium in eyes which underwent a primary surgical removal of BK. Keywords : Nonpreserved amniotic membrane transplantation, Chemical injury, Postinfectious keratitis, Band keratopathy, Topical anesthetic abuse