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S.B. Ankara Ulucanlar Göz Eğitim Hastanesi 1. Göz Kliniği, Ankara, Doç. Dr. Glaucoma, in which the intraocular pressure (IOP) is generally high, is a chronic, progressive neurodegenerative disease and is characterized by loss of retinal ganglion cells and their axons. Advanced visual acuity loss and visual field impairment may occur in the case of delayed diagnosis and inefficient treatment. Although medical or surgical reduction of IOP is the only proven method in the prevention of glaucomatous defects, progression may continue in some cases with decreased IOP. Neuroprotective treatment modalities, which aim to target many factors in the pathogenesis of the disease, are frequently mentioned in recent years. The purpose of this review is to summarize the experimental and clinical researches about neuroprotection which is used in some neurodegenerative disease of central nervous system and to emphasize the importance of neuroprotective treatment in glaucoma. Keywords : Glaucoma, pathophysiology, neuroprotection