Materials and Methods: Between March 2010 and June 2011 a total of 64 cases with chronic and severe vernal keratoconjunctivitis (VKC) were included in the study. Three weeks before the cyclosporine A treatment, topical drugs and systemic antihistamines that patients had been using were stopped. Ophthalmological examination, symptoms and signs severity scores were recorded before treatment and at the first, third and sixth months after treatment. Routine biochemistry and hemogram analysis were performed at the second and sixth months.

Results: Forty six (72%) of the cases were male and eighteen (28%) were female. The mean age was 13±1.4 years. Treatment with topical cyclosporine A decreased symptom severity significantly (p<0.05,Wilcoxon signed rank test). There was no statistically significant differences within clinical signs (p=0.214). Recurrence of symptoms within 2 months was described in 36 (56%) of cases after stopping treatment with topical cyclosporine A. Local and systemic side effects were not observed in the patients. The mean follow-up period was 9±1.2 months.

Conclusion: Using topical cyclosporine A 0.05% in chronic vernal keratoconjunctivitis cases might be effective to control symptom severity and local inflammation but it is insufficient by itself to improve clinical findings. Keywords : Vernal keratoconjunctivitis, cyclosporine A 0.05%.