Material and Methods: Four cases with nanophthalmos were evaluated retrospectively in terms of diagnostic features and treatment approaches. Three of the cases were siblings. Three siblings were female and the other was male. Bilateral laser iridotomy (LI) was applied to one of the sibling cases before being sent to our clinic. Argon laser peripheral iridoplasty (ALPI) was performed in two siblings in our clinic. The youngest sibling case was closely followed for glaucoma development. A trabeculectomy was performed in another center in the eye of the male patient with glaucomatous optic atrophy. Phacoemulsifi cation (Phaco) + viscogoniosynechialysis surgery was performed in the other eye of this patient, whose intraocular pressure (IOP) was not under control with maximal medical treatment.

Results: No complications were encountered in the interventions to the cases. Additional medication (fi x combination) was needed during follow-up.

Conclusion: Patients with nanophthalmos should be carefully monitored for glaucoma development with advancing age. Before the peripheral anterior synechia (PAS) develops, ALPI is valuable for IOP control. According to the degree of development of PAS in angle, synechialysis combined with phaco can provide signifi cant benefi ts in IOP control. However, all interventions to these cases are open to complication development, and close follow-up is required. It should be considered additional medication and/or surgery may be required during follow-up. Keywords : Microphthalmos, nanophthalmos, glaucoma, argon laser peripheral iridoplasty, phacoemulsifi cation, synechialysis