Materials and Methods: In the present study 105 eyes of 75 patients were investigated. Of these patients, 56 eyes of 45 patients who were diagnosed as preperimetric glaucoma are taken as a study group and 49 eyes of 30 cases without any ocular pathology are taken as the control group. The mean values of central MT, parafoveal MT, perifoveal MT, parafoveal GCC thickness, and perifoveal GCC thickness evaluations using optical coherence tomography (OCT) were compared between the two groups. Peripapillary RNFL measurements; the mean values of the total, superior hemi-central, inferior hemi-central, superior, inferior, nasal, and temporal quadrants, and twelve sectors were compared between the two groups.

Results: In the study group, perifoveal GCC thickness was significantly thinner in the superonasal, superotemporal, inferonasal, and inferotemporal quadrants compared to the control group. Peripapillary RNFL thickness was significantly thinner in the study group in total, superior hemi-central, inferior hemi-central, superior, inferior, nasal, temporal, and hour 1,2,3,4,5,7,8,9 quadrants. No significant difference was detected between the two groups in other measurements (p>0.05).

Conclusion: However both macular and peripapillary cellular losses have been initiated in cases with preperimetric glaucoma, this loss can not be detected by standard automated perimetry. As a result, perifoveal GCC and peripapillary RNFL measurements by OCT in patients with preperimetric glaucoma are very helpful for diagnosing suspicious cases. Keywords : Preperimetric glaucoma, Macula thickness, Optical coherence tomography, Ganglion cell complex, Retina nerve fiber layer